Larixol
Larixol is a multi-target small molecule that inhibits fMLP-induced neutrophil activation by blocking key signaling pathways (Src, ERK, p38, AKT) and disrupting Gi protein βγ subunit interactions. It suppresses superoxide generation, cathepsin G release, and chemotaxis (IC50 ~2-3 μM), and its derivatives also inhibit FSGS-linked TRPC6 mutants, supporting research into inflammation and kidney disease.
Product Specifications
CAS Number
1438-66-0
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
C[C@]12[C@@] ([C@@H] (O) CC (=C) [C@@H]1CC[C@] (C=C) (C) O) (C (C) (C) CCC2) [H]
Molecular Formula
C20H34O2
Molecular Weight
306.48
Storage Conditions
-20°C
Notes
For research use only.
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