β5i-IN-1

β5i-IN-1 is a potent and selective β5i inhibitor (IC50 = 8.463 nM) that modulates immune responses by influencing TNF-α, IL-6 release, and NF-κB activity. It serves as a valuable research tool for studying immunoproteasome function in diseases such as idiopathic pulmonary fibrosis, with utility in both in vitro and in vivo experimental models.