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SIKs-IN-1

SIKs-IN-1 (compound 8h) is a potent and selective salt-inducible kinase (SIK) inhibitor that modulates macrophage polarization. It demonstrates anti-inflammatory effects by elevating IL-10 and suppressing IL-12, validated in both cellular assays and a DSS-induced murine colitis model for inflammatory disease research.

Product Specifications

CAS Number

2927557-06-8

Field of Research

Signal Transduction

Smiles

C (NC1=C (C) C=CC=C1F) (=O) C=2C (NC3CCC3) =NC (NC4=CC (F) =C (C=C4) N5CCN (C) CC5) =NC2

Molecular Formula

C27H31F2N7O

Molecular Weight

507.58

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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