SIRT5 inhibitor 7
SIRT5 inhibitor 7 (compound 58) is a selective, substrate-competitive inhibitor (IC50 = 310 nM) . It has demonstrated efficacy in preclinical septic AKI models, reducing renal injury, modulating protein succinylation, and suppressing pro-inflammatory cytokine release in vivo. This inhibitor is a valuable tool for studying sirtuin biology and inflammation-related pathologies.
Product Specifications
CAS Number
2951090-00-7
Field of Research
Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
99.77% (May vary between batches)
Smiles
N (CCCNC (NCCC (O) =O) =S) C=1C (C (=O) N2C[C@H] (CC2) C3=CC=CC=C3) =CN=C (NC4=C (Cl) C=CC=C4) N1
Molecular Formula
C28H32ClN7O3S
Molecular Weight
582.12
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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