DNL343
DNL343 is a brain-penetrant, selective eIF2B activator that suppresses stress granule formation driven by C9ORF72 dipeptide repeats. This molecule is a valuable research tool for investigating pathogenic mechanisms and potential therapeutic strategies in ALS and related neurodegenerative diseases, with utility in both cellular and animal models.
Product Specifications
CAS Number
2278265-85-1
Product Name Alternative
EIF2B, DNL 343, DNL-343
Field of Research
Cell Biology
Purity
99.96% (May vary between batches)
Solubility
DMSO:80 mg/mL (174.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.21 mM)
Smiles
N (C (COC1=CC=C (Cl) C=C1) =O) C23CC (C2) (C3) C=4OC (=NN4) [C@@H]5C[C@H] (OC (F) (F) F) C5
Molecular Formula
C20H19ClF3N3O4
Molecular Weight
457.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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