TRK-IN-23
TRK-IN-23 (compound 24b) is a potent and orally bioavailable pan-TRK inhibitor, demonstrating low nanomolar IC50 values against wild-type TRKA and key solvent-front mutants. It effectively induces apoptosis in Ba/F3 cells harboring TRKA mutations, supporting its utility in preclinical cancer research for studying TRK-driven oncogenesis and resistance mechanisms.
Product Specifications
CAS Number
2924344-29-4
Field of Research
Cell Biology, Signal Transduction
Smiles
C (=C\1/C=2C (NC1=O) =CC=C (NCC3=C (OC) C=CC (F) =C3) C2) \C4=CN=CN4
Molecular Formula
C20H17FN4O2
Molecular Weight
364.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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