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TRK-IN-23

TRK-IN-23 (compound 24b) is a potent and orally bioavailable pan-TRK inhibitor, demonstrating low nanomolar IC50 values against wild-type TRKA and key solvent-front mutants. It effectively induces apoptosis in Ba/F3 cells harboring TRKA mutations, supporting its utility in preclinical cancer research for studying TRK-driven oncogenesis and resistance mechanisms.

Product Specifications

CAS Number

2924344-29-4

Field of Research

Cell Biology, Signal Transduction

Smiles

C (=C\1/C=2C (NC1=O) =CC=C (NCC3=C (OC) C=CC (F) =C3) C2) \C4=CN=CN4

Molecular Formula

C20H17FN4O2

Molecular Weight

364.37

Storage Conditions

-20°C

Notes

For research use only.

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