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TLR7/8 agonist 9

Compound 25a is a potent dual TLR7/8 agonist with EC50 values of 40 nM (hTLR7) and 23 nM (hTLR8) . It exhibits anti-tumor activity and can synergize with PD-1/PD-L1 blockade in cancer immunotherapy research, as supported by studies in both cellular assays and animal models.

Product Specifications

CAS Number

2649170-17-0

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Smiles

N (CCOC) C=1C2=C (C=CC (CC3=CC=C (CN (C) C) C=C3) =N2) N=C (N) N1

Molecular Formula

C20H26N6O

Molecular Weight

366.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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