TLR7/8 agonist 9
Compound 25a is a potent dual TLR7/8 agonist with EC50 values of 40 nM (hTLR7) and 23 nM (hTLR8) . It exhibits anti-tumor activity and can synergize with PD-1/PD-L1 blockade in cancer immunotherapy research, as supported by studies in both cellular assays and animal models.
Product Specifications
CAS Number
2649170-17-0
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology
Smiles
N (CCOC) C=1C2=C (C=CC (CC3=CC=C (CN (C) C) C=C3) =N2) N=C (N) N1
Molecular Formula
C20H26N6O
Molecular Weight
366.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUB3775-100 1x 100 µL
IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) (rIM260), 0.2mg/mL
Sign In for Pricing
View Details 
BNC683340-100 1x 100 µL
CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
