FGFR-IN-11
FGFR-IN-11 is a potent, orally bioavailable covalent inhibitor of FGFR1-4, with IC50 values ranging from 1.8 to 16 nM. It demonstrates robust anti-proliferative activity in cancer cell lines and effectively suppresses tumor growth in mouse xenograft models, supporting its use in oncology research for targeting FGFR-driven cancers.
Product Specifications
CAS Number
2658488-68-5
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C=1C2=C (C=C (OC) C (=C2) C3CCN (C (C=C) =O) CC3) N=CC1) C4=CC (Cl) =C (NC (NC5CC5) =O) C=C4
Molecular Formula
C28H29ClN4O4
Molecular Weight
521.01
Storage Conditions
-20°C
Notes
For research use only.
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