Semapimod
Semapimod is a small molecule that potently inhibits TLR4 signaling (IC50 ~0.3 μM) and suppresses proinflammatory mediators like TNF-α, IL-1β, IL-6, and nitric oxide. Its mechanism, involving p38 MAPK inhibition, supports its research application in models of sepsis, rheumatoid arthritis, and inflammatory bowel disease both in vitro and in vivo.
Product Specifications
CAS Number
352513-83-8
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
C (=NNC (=N) N) (C) C1=CC (C (=NNC (=N) N) C) =CC (NC (CCCCCCCCC (NC2=CC (C (=NNC (=N) N) C) =CC (C (=NNC (=N) N) C) =C2) =O) =O) =C1
Molecular Formula
C34H52N18O2
Molecular Weight
744.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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