PROTAC EGFR degrader 7 diTFA

PROTAC EGFR degrader 7 is a potent and selective CRBN-based degrader of the EGFRL858R/T790M mutant (DC50 = 13.2 nM) . It demonstrates robust anti-proliferative activity (IC50 = 46.82 nM in NCI-H1975 cells), induces apoptosis and G2/M arrest, supporting its application in targeted protein degradation and NSCLC research.