84-B10
Product Specifications
UNSPSC Description
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/84-b10.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(O)CC(CC(NC1=CC(C(F)(F)F)=CC=C1OC2=CC=C(OC)C=C2)=O)C3=CC=CC=C3
Molecular Weight
473.44
References & Citations
[1]Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-44307/84-B10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-44307/84-B10-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
698346-43-9
Available Sizes
Curated Selection
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