Nurr1 agonist 5

Compound 5o is a potent and selective small-molecule agonist of the transcription factor Nurr1 (NR4A2), with a Kd of 0.5 μM and an EC50 of 3 μM. It demonstrates neuroprotective effects in cellular models and is a valuable research tool for studying Parkinson's disease mechanisms in both in vitro and in vivo contexts.