MK-2206 free base
MK-2206 free base is a potent, selective, and orally active allosteric Akt inhibitor with IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It shows activity in breast cancer models with PIK3CA mutations or PTEN loss and has been investigated in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
1032349-93-1
Field of Research
Cell Biology, Signal Transduction
Smiles
O=C1NN=C2C=3C=C (C=4C=CC=CC4) C (=NC3C=CN12) C=5C=CC (=CC5) C6 (N) CCC6
Molecular Formula
C25H21N5O
Molecular Weight
407.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog