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MK-2206 free base

MK-2206 free base is a potent, selective, and orally active allosteric Akt inhibitor with IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It shows activity in breast cancer models with PIK3CA mutations or PTEN loss and has been investigated in both in vitro and in vivo preclinical studies.

Product Specifications

CAS Number

1032349-93-1

Field of Research

Cell Biology, Signal Transduction

Smiles

O=C1NN=C2C=3C=C (C=4C=CC=CC4) C (=NC3C=CN12) C=5C=CC (=CC5) C6 (N) CCC6

Molecular Formula

C25H21N5O

Molecular Weight

407.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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