InS3-54A18
InS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
Product Specifications
CAS Number
328998-53-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/inS3-54A18.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(O)C=C2)C(C3=CC=CC=C3)=C/C1=C/C4=CC=C(Cl)C=C4
Molecular Formula
C23H16ClNO2
Molecular Weight
373.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35 (6) :783-92|[2]Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35 (6) :783-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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