MAT-POS-e194df51-1

MAT-POS-e194df51-1 is a potent, orally bioavailable small molecule inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrating an IC50 of 37 nM. It shows antiviral activity in cellular models, including A549-ACE2-TMPRSS2 (EC50 64 nM) and HeLa-ACE2 (EC50 126 nM) cells, supporting its use in COVID-19 antiviral research.