KY386

KY386 is a potent and selective DHX33 helicase inhibitor (IC50 = 19 nM) with demonstrated anti-cancer activity in DHX33-overexpressing U251-MG glioblastoma cells (IC50 = 20 nM) . It shows moderate metabolic stability and is a useful research tool for investigating DHX33's role in cancer cell proliferation and as a potential therapeutic target in oncology research.