ICMT-IN-35

ICMT-IN-35 (compound 10n) is an FTPA-triazole derivative that inhibits ICMT with an IC50 of 0.8 μM. It disrupts K-Ras membrane localization and demonstrates selective cytotoxicity in cellular models, showing potent activity against metastatic pancreatic cancer cell lines. This inhibitor is a valuable tool for studying Ras biology and oncology research.