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HMGB1-IN-2

HMGB1-IN-2 is a selective HMGB1 inhibitor that at 30 μM reduces IL-1β, TNF-α, and caspase-1 p20 while inhibiting NF-κB phosphorylation in vitro, and at 15 mg/kg i.p. alleviates septic acute kidney injury in mice. It also inhibits Huh7 and A549 cells with IC50 values of 77.0 and 82.0 μM, supporting research in inflammation, sepsis, and cancer.

Product Specifications

Field of Research

Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction

Smiles

COc1ccc (/C=C/C (O[C@H]2CC[C@]3 (C (C2 (C) C) CC[C@@]4 ([C@@H]3C (C=C5C6C[C@@] (C (OCC7=NN (C8OC (C) C (OC (C) =O) C (OC (C) =O) C8) N=C7) =O) (CC[C@@]6 (CC[C@]54C) C) C) =O) C) C) =O) cc1

Molecular Formula

C53H71N3O11

Molecular Weight

926.14

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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