Cisd2 agonist 2

Cisd2 agonist 2 (compound 6) is a potent, orally bioavailable small molecule activator of Cisd2 (EC50=191 nM), a target implicated in nonalcoholic fatty liver disease (NAFLD) . It has demonstrated in vivo efficacy without significant toxicity in Cisd2hKO-het mouse models, supporting its use in metabolic and liver disease research.