CDK9-Cyclin T1 PPI-IN-1

CDK9-Cyclin T1 PPI-IN-1 is a selective protein-protein interaction inhibitor that suppresses proliferation and induces apoptosis in TNBC cells (IC50=0.044 μM) . It reduces CDK9-mediated transcription and RNA Pol II phosphorylation, demonstrating in vivo efficacy against 4T1 tumor growth in mice, supporting its use in oncology research.