Finerenone
Finerenone (BAY 94-8862) is a potent, selective, orally available mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM; displays excellent selectivity (>500-fold) versus GR, AR, and PR, also shows no L type Ca2+ channel activity; elicits a significant and dose-dependent increase in the urinary sodium/potassium ratio in vivo, with a MED of 0.3 mg kg1 p.o.; exhibits three- to tenfold greater potency and higher efficacy in acute rat natriuresis model compared with eplerenone, demonstrates potential for the treatment of chronic heart failure (CHF) .Heart FailurePhase 3 Clinical (In Vivo) :Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Fr mter (MWF) rat.
Product Specifications
CAS Number
1050477-31-0
Product Name Alternative
BAY 94-8862 | BAY 948862
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 200 mg/mL (528.51 mM)
Smiles
O=C (C1=C (C) NC2=C (C (OCC) =NC=C2C) [C@@H]1C3=CC=C (C#N) C=C3OC) N
Molecular Formula
C21H22N4O3
Molecular Weight
378.432
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4S) -4- (4-Cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
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