Tafenoquine
Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.Parasite Infection Phase 3 Clinical (In Vitro) :Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg) .
Product Specifications
CAS Number
106635-80-7
Product Name Alternative
SB-252263 | Tafenoquine | WR 238605
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
CC1=CC (=NC2=C1C (=C (C=C2NC (C) CCCN) OC) OC3=CC=CC (=C3) C (F) (F) F) OC
Molecular Formula
C24H28F3N3O3
Molecular Weight
463.501
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N4- (2,6-dimethoxy-4-methyl-5- (3- (trifluoromethyl) phenoxy) quinolin-8-yl) pentane-1,4-diamine
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