Imarikiren hydrochloride
A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM) ; exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo.Diabetes Phase 2 Clinical.
Product Specifications
CAS Number
1202269-24-6
Product Name Alternative
TAK-272 | TAK 272 hydrochloride | TAK272
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) CN (C1CC (CNC1) C (=O) N2CCOCC2) C (=O) C3=NC4=CC=CC=C4N3CCCCOC.Cl
Molecular Formula
C27H42ClN5O4
Molecular Weight
536.114
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4-methoxybutyl) -N- (2-methylpropyl) -N-[ (3S,5R) -5- (morpholin-4-yl) carbonylpiperidin-3-yl]-1H-benzimidazole-2-carboxamide hydrochloride
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