AS 2444697
A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1; inhibited IL-1β- or TLR ligand lipopolysaccharide (LPS) -induced IL-6 production in human lung alveolar epithelial cells, fibroblast-like synoviocytes, and peripheral blood mononuclear cells; significantly reduces urinary protein excretion and preventd the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure in mice model of chronic kidney disease.
Product Specifications
CAS Number
1287665-60-4
Product Name Alternative
AS2444697 | AS-2444697
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 12.5 mg/mL (28.88 mM)
Smiles
CC1=NC=CC (=C1) C2=NC (=CO2) C (=O) NC3=CN (N=C3C (=O) N) C4CCOCC4.Cl
Molecular Formula
C19H21ClN6O4
Molecular Weight
432.865
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[3-carbamoyl-1- (tetrahydro-2H-pyran-4-yl) -1H-pyrazol-4-yl]-2- (2-methylpyridin-4-yl) -1,3-oxazole-4-carboxamide hydrochloride
Available Sizes
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