Verdinexor
Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively; induces apoptosis in CLBL1 cells and primary canine DLBCL cells; reduces influenza a virus replication in vitro and in vivo; also inhibits XPO1-mediated transport and reduces RSV replication in vitro, shows effectivity against RSV A and B strains and reduces viral replication following prophylactic or therapeutic administration.Influenza Phase 1 Clinical.
Product Specifications
CAS Number
1392136-43-4
Product Name Alternative
KPT-335 | KPT335
Purity
>98% (HPLC)
Solubility
DMSO: 82 mg/mL (185.4 mM) ; Ethanol: 9 mg/mL (20.3 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NNC1=NC=CC=C1) /C=C\N2N=C (C3=CC (C (F) (F) F) =CC (C (F) (F) F) =C3) N=C2
Molecular Formula
C19H13F6N5O
Molecular Weight
441.337
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(Z) -3- (3- (3,5-bis (trifluoromethyl) phenyl) -1H-1,2,4-triazol-1-yl) -N- (pyridin-2-ylmethyl) acrylamide
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