Acalisib
Acalisib is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.
Product Specifications
CAS Number
870281-34-8
Product Name Alternative
GS-9820; CAL-120
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Acalisib.html
Purity
99.98
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C=C(F)C=C5
Molecular Formula
C21H16FN7O
Molecular Weight
401.40
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Shugg RP, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem. 2013 Dec 6;288 (49) :35346-57.|[2]Lopez-Guadamillas E, et al. PI3Kα inhibition reduces obesity in mice. Aging (Albany NY) . 2016 Nov 4;8 (11) :2747-2753.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
Available Sizes
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