Acalisib

Acalisib is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.

Product Specifications

CAS Number

[870281-34-8]

Product Name Alternative

GS-9820; CAL-120

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Acalisib.html

Purity

99.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C=C(F)C=C5

Molecular Formula

C21H16FN7O

Molecular Weight

401.40

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shugg RP, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem. 2013 Dec 6;288 (49) :35346-57.|[2]Lopez-Guadamillas E, et al. PI3Kα inhibition reduces obesity in mice. Aging (Albany NY) . 2016 Nov 4;8 (11) :2747-2753.