Gypenoside XLIX

Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR) -alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells[1].

Product Specifications

CAS Number

[94987-08-3]

UNSPSC

12352005

Target

PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gypenoside-xlix.html

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C[C@@]([C@](CC1)([H])C2(C)C)(CC[C@@H]2O[C@@](OC[C@H](O)[C@@H]3O[C@@](OC[C@@H](O)[C@@H]4O)([H])[C@@H]4O)([H])[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)[C@](CC[C@@]6([H])[C@]7(CC[C@]6([H])[C@](CC/C=C(C)/C)(O)CO[C@@H]([C@@H]([C@@H](O)[C@@H]8O)O)O[C@@H]8CO)C)([H])[C@]71C

Molecular Formula

C52H86O21

Molecular Weight

1047.23

References & Citations

[1]Huang TH , et al. Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. Eur J Pharmacol. 2007 Jun 22;565 (1-3) :158-65.