D359-0396
D359-0396 is a potent, orally bioavailable NLRP3 inflammasome inhibitor that blocks NLRP3-ASC oligomerization and GSDMD cleavage, suppressing pyroptosis and IL-1β secretion in macrophages. It demonstrates efficacy in preclinical models, including reducing severity in Experimental Autoimmune Encephalomyelitis (EAE) and improving survival in murine septic shock.
Product Specifications
CAS Number
1031977-31-7
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
O=C1C2=CN3C=4C=CC=CC4NC (C5=CC=C (C=C5) C (C) C) C3=C2N (C (=O) N1C) C
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Storage Conditions
-20°C
Notes
For research use only.
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