D359-0396
D359-0396 is a potent, orally bioavailable NLRP3 inflammasome inhibitor that blocks NLRP3-ASC oligomerization and GSDMD cleavage, suppressing pyroptosis and IL-1β secretion in macrophages. It demonstrates efficacy in preclinical models, including reducing severity in Experimental Autoimmune Encephalomyelitis (EAE) and improving survival in murine septic shock.
Product Specifications
CAS Number
1031977-31-7
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
O=C1C2=CN3C=4C=CC=CC4NC (C5=CC=C (C=C5) C (C) C) C3=C2N (C (=O) N1C) C
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IKB19538-01 50 mg
2-Amino-4H,5H,6H,7H,8H-cyclohepta[D][1,3]thiazol-8-one
Sign In for Pricing
View Details IKB19538-02 0.5 g
2-Amino-4H,5H,6H,7H,8H-cyclohepta[D][1,3]thiazol-8-one
Sign In for Pricing
View Details 