PF-05089771
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8; interacts with the voltage-sensor domain (VSD) of domain IV, blocks all Nav1.7 splice variants with similar potency (5N11L, 5A11S, 5A11L and 5N11S, IC50s=11=33 nM) ; displays high selectivity over L-type calcium channels, KvLQT and hERG potassium channels; demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.
Product Specifications
CAS Number
1430806-04-4
Product Name Alternative
PF05089771
Purity
>98% (HPLC)
Smiles
CC1=CC=C (C=C1) S (=O) (=O) O.C1=CC (=C (C=C1Cl) C2=C (NN=C2) N) OC3=CC (=C (C=C3Cl) S (=O) (=O) NC4=CSC=N4) F
Molecular Formula
C18H12Cl2FN5O3S2
Molecular Weight
500.344
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[2- (5-amino-1H-pyrazol-4-yl) -4-chlorophenoxy]-5-chloro-2-fluoro-N- (1,3-thiazol-4-yl) benzenesulfonamide
Available Sizes
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