BGB-283
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM) ; inhibits recombinant BRAFV600E with IC50 of 23 nM; also inhibits EGFR and EGFR T790M/L858R with IC50 of 29 nM and 495 nM respectively; potently inhibits BRAF (V600E) -activated ERK phosphorylation and cell proliferation in vitro; shows tumor growth inhibition in both cell line-derived and primary human colorectal tumor xenografts bearing BRAF (V600E) mutation.Colon Cancer Preclinical.
Product Specifications
CAS Number
1446090-77-2
Product Name Alternative
Lifirafenib | BGB 283 | BGB283
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 125 mg/mL
Smiles
[H][C@@]1 (C2=CC (OC3=C (CCC4=O) C (N4) =NC=C3) =CC=C2O[C@]51[H]) [C@@H]5C6=NC7=CC=C (C=C7N6) C (F) (F) F
Molecular Formula
C25H17F3N4O3
Molecular Weight
478.4227
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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