GS-5734
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.Ebola Virus Infection Phase 2 Clinical (In Vitro) :Remdesivir (GS-5734) inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h.
Product Specifications
CAS Number
1809249-37-3
Product Name Alternative
GS 5734 | GS5734 | Remdesivir
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 125 mg/mL 207.44 mM
Smiles
CCC (CC) COC ([C@H] (C) N[P@] (OC[C@H]1O[C@] (C2=CC=C3N2N=CC=C3N) (C#N) [C@H] (O) [C@@H]1O) (OC4=CC=CC=C4) =O) =O
Molecular Formula
C28H36N5O8P
Molecular Weight
601.597
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
