Tipifarnib S enantiomer

Tipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase) ; inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively; no activity for PGGT1 (IC50>50 uM) ; shows sensiticity for tumor cell lines bearing H-ras or N-ras mutations; inhibits the growth of tumors bearing mice and orally bioavailable.Blood Cancer Phase 3 Clinical.