GNE-6640
GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM) ; promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM. (In Vitro) :GNE-6640 promotes endogenous MDM2 ubiquitination with Lys48 (K48) -linked polyubiquitin chains, which directs proteasomal degradation13. GNE-6640 targets cellular USP7, MDM2, and p53 signalling pathways. GNE-6640 decreases viability of 108 cell lines with IC50 ≤ 10 μM. Combining GNE-6640 with doxorubicin or cisplatin (DNA-damaging agents), which could activate the p53 response and enhance USP7 inhibitor efficacy. GNE-6640 could induce tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
Product Specifications
CAS Number
2009273-67-8
Product Name Alternative
GNE 6640 | GNE6640
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC1=CC=C (C2=C (CC) C (C3=CC4=C (NN=C4) C=C3) =CN=C2N) C=C1
Molecular Formula
C20H18N4O
Molecular Weight
330.391
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[2-Amino-4-ethyl-5- (1H-indazol-5-yl) -3-pyridyl]phenol
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ADRA1B, ID (ADRA1B, Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor) (Azide free) (HRP) discontinued
CCL19 (C-C Motif Chemokine 19, Small Inducible Cytokine A19, Macrophage Inflammatory Protein 3 beta, MIP-3-beta, Epstein-Barr Virus-induced Molecule 1 Ligand Chemokine, EBI1-ligand Chemokine, ELC, Beta Chemokine Exodus-3, CK beta-11, MIP3B, SCYA19, MGC34433) (AP) discontinued
