Setmelanotide
Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively; exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM) ; acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.Obesity Phase 3 Clinical.
Product Specifications
CAS Number
920014-72-8
Product Name Alternative
RM-493 | BIM-22493 | IRC-022493
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
Molecular Formula
C49H68N18O9S2
Molecular Weight
1117.309
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8) -disulfide
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