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Amikacin disulfate

Amikacin sulfate (BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. (In Vitro) :Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi) .Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM. (In Vivo) :Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.

Product Specifications

CAS Number

39831-55-5

Product Name Alternative

BAY-416651 sulfate

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

H2O : ≥ 50 mg/mL; 63.96 mM

Smiles

OS (O) (=O) =O.OS (O) (=O) =O.NCC[C@H] (O) C (=O) N[C@@H]1C[C@H] (N) [C@@H] (O[C@H]2O[C@H] (CN) [C@@H] (O) [C@H] (O) [C@H]2O) [C@H] (O) [C@H]1O[C@H]1O[C@H] (CO) [C@@H] (O) [C@H] (N) [C@H]1O

Molecular Formula

C22H43N5O13·2H2O4S

Molecular Weight

781.76

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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