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Aminopterin

Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase. (In Vitro) :The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM.Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes.

Product Specifications

CAS Number

54-62-6

Product Name Alternative

4-Aminofolic acid | APGA

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 14.71 mg/mL (33.40 mM)

Smiles

Nc1nc (N) c2nc (CNc3ccc (C (=O) N[C@@H] (CCC (=O) O) C (=O) O) cc3) cnc2n1

Molecular Formula

C19H20N8O5

Molecular Weight

440.41

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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