Aminopterin
Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase. (In Vitro) :The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM.Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes.
Product Specifications
CAS Number
54-62-6
Product Name Alternative
4-Aminofolic acid | APGA
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 14.71 mg/mL (33.40 mM)
Smiles
Nc1nc (N) c2nc (CNc3ccc (C (=O) N[C@@H] (CCC (=O) O) C (=O) O) cc3) cnc2n1
Molecular Formula
C19H20N8O5
Molecular Weight
440.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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