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Bosutinib hydrate

Bosutinib (hydrate) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range.IC50: 314 nmol/L (Csk, Src family protein tyrosine kinases) ; IC50: 2.4 nmol/L (Abl kinase) .

Product Specifications

CAS Number

918639-08-4

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (182.33 mM)

Smiles

CN1CCN (CC1) CCCOC2=C (C=C3C (NC4=CC (OC) =C (C=C4Cl) Cl) =C (C=NC3=C2) C#N) OC.O

Molecular Formula

C26H31Cl2N5O4

Molecular Weight

548.46

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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