Bosutinib hydrate
Bosutinib (hydrate) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range.IC50: 314 nmol/L (Csk, Src family protein tyrosine kinases) ; IC50: 2.4 nmol/L (Abl kinase) .
Product Specifications
CAS Number
918639-08-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (182.33 mM)
Smiles
CN1CCN (CC1) CCCOC2=C (C=C3C (NC4=CC (OC) =C (C=C4Cl) Cl) =C (C=NC3=C2) C#N) OC.O
Molecular Formula
C26H31Cl2N5O4
Molecular Weight
548.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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