2614W94
2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate. (In Vitro) :2614W94 (30 nM) shows no inhibition of MAO-B. (In Vivo) :In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg.
Product Specifications
CAS Number
205187-35-5
Purity
>98% (HPLC)
Smiles
CC (Oc1ccc2c (Oc3ccccc3S2 (=O) =O) c1) C (F) (F) F
Molecular Formula
C15H11F3O4S
Molecular Weight
344.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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