7-Chlorokynurenic acid
7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery. (In Vivo) :In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.
Product Specifications
CAS Number
18000-24-3
Product Name Alternative
7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 16.67 mg/mL (74.55 mM)
Smiles
O=C (O) C=1N=C2C=C (Cl) C=CC2=C (O) C1
Molecular Formula
C10H6ClNO3
Molecular Weight
223.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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