AL 8697
AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. (In Vivo) :In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw.
Product Specifications
CAS Number
1057394-06-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (248.50 mM)
Smiles
Cc1c (F) cc (cc1-c1c (F) cn2c (nnc2c1F) C (C) (C) C) C (=O) NC1CC1
Molecular Formula
C21H21F3N4O
Molecular Weight
402.421
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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