2-Methyl-5-HT

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].

Product Specifications

CAS Number

[78263-90-8]

Product Name Alternative

2-Methyl-5-hydroxytryptamine; 2-Methylserotonin; 2-Me-5-HT

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-methyl-5-ht.html

Concentration

10mM

Purity

98.93

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(NC(C)=C2CCN)C=C1

Molecular Formula

C11H14N2O

Molecular Weight

190.24

Precautions

H302, H312, H332

References & Citations

[1]Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.