Niraparib (R-enantiomer)
Niraparib R-enantiomer is an inhibitor of PARP1 (IC50 of 2.4 nM) . (In Vitro) :Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM) . .
Product Specifications
CAS Number
1038915-58-0
Product Name Alternative
Niraparib R-enantiomer | MK 4827 (R-enantiomer)
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 32 mg/mL (99.88 mM)
Smiles
NC (=O) c1cccc2cn (nc12) -c1ccc (cc1) [C@H]1CCCNC1
Molecular Formula
C19H20N4O
Molecular Weight
320.396
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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