Glufosinate ammonium

Glufosinate ammonium is a phosphinic acid analogue of glutamic acid and is an herbicide. Glufosinate ammonium is converted by plant cells into PT (L-phosphinothricin) . Glufosinate ammonium has neurotoxic activity. (In Vitro) :Glufosinate ammonium impairs ependymal cell capability to synthetize cilia. Glufosinate ammonium (1-100 μM; 12DIV) obviously reduces Celsr2 gene expression at 100 μM. Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs) . (In Vivo) :In Wistar rats, Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) shows maternal toxicity in the groups given 50 or 250 mg/kg. In male and female rats, the Elimination of Glufosinate ammonium in the blood takes place with a half-life of less than 4 hours.