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JNJ-61432059

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR (pIC50: 9.7) . (In Vivo) :In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

Product Specifications

CAS Number

2035814-50-5

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 50 mg/mL (112.75 mM)

Smiles

OC1CCN (CC1) c1nccc2c (c (nn12) -c1ccc (F) cc1) -c1ccc2NC (=O) Cc2c1

Molecular Formula

C25H22FN5O2

Molecular Weight

443.482

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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